Autobiographical memory in progressive supranuclear palsy.

BACKGROUND We aimed to investigate recall of autobiographical memories across lifetime periods in patients with progressive supranuclear palsy (PSP). METHOD Patients with PSP (n = 10) were given a test of autobiographical and personal semantic information and the Addenbrooke's Cognitive Examination (ACE). The result was compared to 30 matched neurologically intact participants. RESULT A mild autobiographical memory impairment was observed in PSP without a temporal gradient for the recall of autobiographical or personal semantic information. Performance correlated with verbal fluency in ACE. CONCLUSION Patients with PSP show mild deficits in autobiographical memory, which is likely to reflect a frontal retrieval deficit.